Josie Totah began her career as a child actor with a recurring role on the Disney Channel series Jessie. She is known for her starring roles on the 2013 ABC comedy series Back in the Game, and the 2018 NBC comedy series Champions with Mindy Kaling. Formerly known as J.J., she came out on August 20, 2018 as transgender.

Totah began her acting career in 2012 when she was cast as the "Lil' Dictator" in the first production for AwesomenessTV. Beginning in 2013, she began appearing as Stuart Wooten, a boy with a crush on series regular Zuri Ross, in the Disney Channel Original Series Jessie. Josie has guest starred on the TV shows, New Girl, 2 Broke Girls, and Liv and Maddie. In 2015, she was cast in 4 episodes of the sixth season of Glee as the youngest member ever of the New Directions.

In 2016, she appeared as Justin in the film Other People, and received critical praise for her role with Variety, making her one of its Sundance Breakout Stars of the year. In 2017, she appeared in the Netflix detective comedy Handsome: A Netflix Mystery Movie and the Marvel Studios film Spider Man: Homecoming.

In January 2017 it was reported by Variety that Totah had joined Adam Devine in the Disney feature film Magic Camp.

Josie is a supporter of STOMP Out Bullying. Hear her anti-bullying message,